Module: D_GO:0007169
Name = transmembrane receptor protein tyrosine kinase signaling pathway
Definition = A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription.
Response module--------
Number of tumors that hit the module: 196
Number of genes in the module: 28
Genes in the module: ANGPTL1;
ARHGEF4;
ARID5B;
DDR2;
DUSP6;
EFEMP1;
EGFR;
EPHB1;
FGF14;
FGF2;
FGF7;
FIGF;
FOXC1;
FOXO1;
KIT;
KL;
NDN;
NGFR;
NRG1;
NTRK2;
NTRK3;
PCSK5;
PDE3B;
PDGFRA;
PRKD1;
SORBS1;
SPRY1;
SPRY2;
Modu-hit surivval risk:-------
Perturbation module-------
Number of genes in the module: 30
Genes in the module: TCEB1(20c);
UBE2W(19c);
AZIN1(1s, 16c);
CCT2(1s, 11c);
PBXIP1(1s, 8c);
USP15(3s, 5c);
BIRC5(7c);
MAFG(7c);
UBE2V2(7c);
CAND1(1s, 5c);
TSG101(2s, 3c);
FANCA(4s, 1c);
GSPT1(4s, 1c);
CUL2(4c);
SELENBP1(4c);
RNF2(4c);
BIRC2(3c);
DPPA2(1s, 2c);
TOPORS(2s, 1c);
MED31(3c);
HSP90AA1(1s, 2c);
VSIG8(2s);
GTF2I(1s, 1c);
MEPCE(2c);
TFCP2(1s, 1c);
PSMD7(1s, 1c);
MOAP1(1s);
HIF1A(1c);
MKRN3(1s);
TRIM39;
Color Codes: 
