Module: D_GO:0007186
    Name = G-protein coupled receptor signaling pathway
    Definition = A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.

Response module--------
    Number of tumors that hit the module: 237
    Number of genes in the module: 26
    Genes in the module: AKAP12; AKR1C3; CXCL1; CXCL12; DAPL1; DARC; DEFB1; EDN1; ENPP2; GABRE; GNAI1; GNG11; GPR146; GPR64; HTR2A; LPHN2; LPHN3; NMB; NMUR1; NPY2R; OXGR1; OXTR; P2RY12; PENK; SSTR1; TAC1;
    Modu-hit surivval risk:-------

Perturbation module-------
    Number of genes in the module: 33
    Genes in the module: PHB(1s, 25c); TCEB1(20c); UBE2W(19c); SCAMP3(14c); DDX5(12c); PBXIP1(2s, 8c); CPT1A(2s, 7c); NSF(1s, 7c); MDM2(1s, 7c); NCOA2(1s, 6c); NUP93(1s, 5c); PAK1(2s, 4c); TSG101(2s, 3c); RAD18(2s, 3c); ARRB1(1s, 4c); SRRM2(5s); RNF2(5c); UBE2N(5c); BIRC8(4s); RAF1(1s, 3c); SNW1(2s, 2c); GTF2H1(1s, 2c); GTF2F1(3c); HDAC1(1s, 1c); HIF1A(1s, 1c); PAN2(2s); GTF2I(1s, 1c); POU4F2(2s); TFCP2(1s, 1c); PCBD2(1c); CLN3(1s); ESR1(1s); TRIM27;

    Color Codes: