Name = G-protein coupled receptor signaling pathway
Definition = A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.
Number of tumors that hit the module: 237
Number of genes in the module: 26
Genes in the module: AKAP12;
Modu-hit surivval risk:-------
Number of genes in the module: 33
Genes in the module: PHB(1s, 25c);