Module: D_GO:0007186
Name = G-protein coupled receptor signaling pathway
Definition = A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.
Response module--------
Number of tumors that hit the module: 237
Number of genes in the module: 26
Genes in the module: AKAP12;
AKR1C3;
CXCL1;
CXCL12;
DAPL1;
DARC;
DEFB1;
EDN1;
ENPP2;
GABRE;
GNAI1;
GNG11;
GPR146;
GPR64;
HTR2A;
LPHN2;
LPHN3;
NMB;
NMUR1;
NPY2R;
OXGR1;
OXTR;
P2RY12;
PENK;
SSTR1;
TAC1;
Modu-hit surivval risk:-------
Perturbation module-------
Number of genes in the module: 33
Genes in the module: PHB(1s, 25c);
TCEB1(20c);
UBE2W(19c);
SCAMP3(14c);
DDX5(12c);
PBXIP1(2s, 8c);
CPT1A(2s, 7c);
NSF(1s, 7c);
MDM2(1s, 7c);
NCOA2(1s, 6c);
NUP93(1s, 5c);
PAK1(2s, 4c);
TSG101(2s, 3c);
RAD18(2s, 3c);
ARRB1(1s, 4c);
SRRM2(5s);
RNF2(5c);
UBE2N(5c);
BIRC8(4s);
RAF1(1s, 3c);
SNW1(2s, 2c);
GTF2H1(1s, 2c);
GTF2F1(3c);
HDAC1(1s, 1c);
HIF1A(1s, 1c);
PAN2(2s);
GTF2I(1s, 1c);
POU4F2(2s);
TFCP2(1s, 1c);
PCBD2(1c);
CLN3(1s);
ESR1(1s);
TRIM27;
Color Codes: 
