Module: D_GO:0019932
Name = second-messenger-mediated signaling
Definition = Any intracellular signal transduction in which the signal is passed on within the cell via a second messenger; a small molecule or ion that can be quickly generated or released from intracellular stores, and can diffuse within the cell. Second-messenger signaling includes production or release of the second messenger, and effectors downstream of the second messenger that further transmit the signal within the cell.
Response module--------
Number of tumors that hit the module: 189
Number of genes in the module: 20
Genes in the module: ADM;
ADRB2;
CD36;
EDN1;
EDN3;
EDNRB;
FOXO1;
FZD7;
GSN;
HTR2A;
IGF1;
NMUR1;
NR4A1;
P2RY12;
PDE2A;
PDGFRA;
PIK3C2G;
PTGER4;
RCAN1;
SSTR1;
Modu-hit surivval risk:-------
Perturbation module-------
Number of genes in the module: 39
Genes in the module: TCEB1(19c);
UBE2W(17c);
TERF1(13c);
NBN(12c);
NIT1(10c);
VDAC2(2s, 6c);
PARD6B(1s, 6c);
SORBS3(2s, 4c);
WRN(5c);
NUP93(1s, 4c);
MBD1(1s, 4c);
UBC(4s, 1c);
TSG101(1s, 3c);
DTX3(4c);
PLEKHF2(1s, 3c);
KPNB1(4c);
MAX(3s, 1c);
GTF3A(1s, 3c);
RNF2(4c);
ATF7IP(2s, 1c);
DLG5(1s, 2c);
KPNA3(1s, 2c);
GTF2H1(1s, 2c);
RNF41(2s, 1c);
TFAP2A(2s, 1c);
MSH2(2s);
RFC1(2s);
HIF1A(1s, 1c);
CBX4(1s, 1c);
SH3GL2(2s);
PAN2(2s);
GPBP1L1(1s, 1c);
ATF2(1s, 1c);
CLN3(1s);
XRCC6(1s);
RAC1(1c);
ESR1(1s);
PRLR;
TCEA2;
Color Codes: 
