Module: D_GO:0030154
Name = cell differentiation
Definition = The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
Response module--------
Number of tumors that hit the module: 346
Number of genes in the module: 49
Genes in the module: ACVR1C;
ADIPOQ;
ADRB2;
AKR1C3;
ANGPTL4;
ANXA1;
ATOH8;
BCL11A;
BMP2;
BMP6;
BOC;
CAV1;
CHL1;
CHRDL1;
EDN3;
EGR1;
EGR2;
FABP4;
FGF2;
FHL1;
FIGF;
FOXC1;
FZD7;
GPC3;
GPM6B;
HOXA7;
ID4;
IGF1;
IGSF10;
KIT;
KRT14;
LAMB3;
LY6D;
MRAP;
NDRG2;
NFIB;
NNAT;
NR0B1;
NTRK2;
OSR1;
PDE2A;
PID1;
PPARG;
RGS2;
RUNX1T1;
SFRP1;
SLC2A4;
SOX10;
TP63;
Modu-hit surivval risk:-------
Perturbation module-------
Number of genes in the module: 36
Genes in the module: MED13(4s, 35c);
RPS6KB1(37c);
USP32(1s, 32c);
SUPT4H1(31c);
OTUD7B(3s, 25c);
ATF6(2s, 24c);
PSMC5(21c);
RTN4IP1(1s, 19c);
IKBKB(3s, 15c);
HAX1(15c);
ADRM1(1s, 12c);
WWP1(1s, 11c);
PPP1CA(11c);
CTCF(10s, 1c);
AKT1(10s);
UBC(5s, 1c);
TRRAP(5s);
CSNK2A2(1s, 4c);
RICTOR(3s, 1c);
SMC1A(3s, 1c);
RTN4(3s, 1c);
E2F4(2s, 2c);
MAX(3s, 1c);
HSP90AA1(2s, 2c);
ATF2(2s, 2c);
NOTCH1(2s, 1c);
BTK(3s);
HDAC3(1s, 1c);
ERCC3(2s);
CREB1(1s, 1c);
CSNK2A1(1s, 1c);
EWSR1(2s);
ACTA1(1s);
YY1(1c);
HIF1AN;
EIF3F;
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